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Symptoms Urinary urgency, frequency, and pain in the absence of infection Lower abdominal pressure Pain upon bladder filling or emptying Painful sex Painful orgasm Generalized pelvic pain Nocturia (waking at night to urinate) Symptoms Urinary urgency, frequency, and pain in the absence of infection Lower abdominal pressure Pain upon bladder filling or emptying Painful sex Painful orgasm Generalized pelvic pain Nocturia (waking at night to urinate) Associated Diagnoses IC/PBS is considered a chronic overlapping pain condition (COPC)

doi: 10.1002/pmic.201600322 179 RaimoS.SantangeloG.TrojanoL

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BBB-permeable HGF/BDNF mimetic that drives synapse formation, rescues memory in AD and TBI models, and shows an 812-day half-life for convenient daily use

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